![\"\"](\"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/06\/900-0-1750749424xscreenshot-16-878.webp?resize=689%2C393&ssl=1\")
<\/p>\n<\/p>\n
28 Qershor 2025<\/p>\n
Studiues t\u00eb udh\u00ebhequr nga Universiteti i Pensilvanis\u00eb e kan\u00eb shnd\u00ebrruar k\u00ebrpudh\u00ebn vdekjeprur\u00ebse Aspergillus flavus, e lidhur me mallkimin e faraon\u00ebve, n\u00eb nj\u00eb p\u00ebrb\u00ebr\u00ebs t\u00eb fuqish\u00ebm q\u00eb lufton kancerin, duke hapur rrug\u00eb t\u00eb reja p\u00ebr zbulimin e m\u00eb shum\u00eb ila\u00e7eve me baz\u00eb k\u00ebrpudhat.<\/p>\n
Pasi arkeolog\u00ebt hap\u00ebn varrin e mbretit Tutankhamun n\u00eb vitet 1920, nj\u00eb seri vdekjesh t\u00eb parakohshme midis ekipit t\u00eb g\u00ebrmimeve nxit\u00ebn thashethemet p\u00ebr nj\u00eb mallkim t\u00eb faraonit. Dekada m\u00eb von\u00eb, mjek\u00ebt teorizuan se sporet e k\u00ebrpudhave, t\u00eb fjetura p\u00ebr mij\u00ebvje\u00e7ar\u00eb, mund t\u00eb ken\u00eb luajtur nj\u00eb rol.<\/p>\n
N\u00eb vitet 1970, dymb\u00ebdhjet\u00eb shkenc\u00ebtar\u00eb hyn\u00eb n\u00eb varrin e Kazimirit IV n\u00eb Poloni. Brenda pak jav\u00ebsh, dhjet\u00eb prej tyre vdiq\u00ebn. Hulumtimet e m\u00ebvonshme zbuluan se varri p\u00ebrmbante Aspergillus flavus, toksinat e t\u00eb cilit mund t\u00eb \u00e7ojn\u00eb n\u00eb infeksione t\u00eb mushk\u00ebrive, ve\u00e7an\u00ebrisht tek njer\u00ebzit me sistem imunitar t\u00eb dob\u00ebsua.<\/p>\n
Tani, e nj\u00ebjta k\u00ebrpudh\u00eb \u00ebsht\u00eb burimi i nj\u00eb trajtimi t\u00eb ri premtues p\u00ebr kancerin.<\/p>\n
\u201cK\u00ebrpudhat na dhan\u00eb penicilin\u00eb. K\u00ebto rezultate tregojn\u00eb se ka shum\u00eb m\u00eb tep\u00ebr ila\u00e7e t\u00eb nxjerra nga produkte natyrore q\u00eb mund t\u00eb gjenden\u201d,<\/em>\u00a0thot\u00eb Sheri Gao, profesoresh\u00eb e asociuar e Inxhinieris\u00eb Kimike dhe Biomolekulare dhe Bioteknologjis\u00eb dhe autore kryesore e punimit n\u00eb Nature Chemical Biology.<\/p>\n Trajtimi n\u00eb fjal\u00eb \u00ebsht\u00eb nj\u00eb klas\u00eb peptidesh t\u00eb sintetizuara n\u00eb ribosom dhe t\u00eb modifikuara pas p\u00ebrkthimit (RiPP). Nd\u00ebrsa mij\u00ebra RiPP jan\u00eb identifikuar n\u00eb baktere, vet\u00ebm disa jan\u00eb gjetur n\u00eb k\u00ebrpudha. P\u00ebr t\u00eb gjetur m\u00eb shum\u00eb RiPP nga k\u00ebrpudhat, studiuesit studiuan s\u00eb pari nj\u00eb duzin\u00eb llojesh t\u00eb Aspergillus, t\u00eb cilat hulumtimet e m\u00ebparshme kishin sugjeruar se mund t\u00eb p\u00ebrmbanin m\u00eb shum\u00eb nga k\u00ebto kimikate, dhe zbuluan se Aspergillus flavus mbante premtimin m\u00eb t\u00eb madh p\u00ebr studime t\u00eb m\u00ebtejshme.<\/p>\n Pas pastrimit t\u00eb kat\u00ebr RiPP-ve t\u00eb ndryshme, studiuesit zbuluan se molekulat ndanin nj\u00eb struktur\u00eb unike t\u00eb unazave t\u00eb nd\u00ebrlidhura. Studiuesit i em\u00ebruan k\u00ebto molekula, t\u00eb cilat nuk ishin p\u00ebrshkruar kurr\u00eb m\u00eb par\u00eb, sipas k\u00ebrpudh\u00ebs n\u00eb t\u00eb cil\u00ebn u gjet\u00ebn: aspergillomicina.<\/p>\n Edhe pa modifikim, kur u p\u00ebrzien me qelizat kancerogjene njer\u00ebzore, aspergomicinat treguan premtim mjek\u00ebsor: dy nga kat\u00ebr variantet kishin efekte t\u00eb fuqishme kund\u00ebr qelizave t\u00eb leu\u00e7emis\u00eb. Nj\u00eb variant tjet\u00ebr, t\u00eb cilit studiuesit i shtuan nj\u00eb lipid, ose molekul\u00eb yndyrore, q\u00eb gjendet gjithashtu n\u00eb pelten\u00eb mbret\u00ebrore q\u00eb ushqen blet\u00ebt n\u00eb zhvillim, funksionoi po aq mir\u00eb sa citarabina dhe daunorubicina, dy ila\u00e7e t\u00eb miratuara nga FDA q\u00eb jan\u00eb p\u00ebrdorur p\u00ebr dekada p\u00ebr t\u00eb trajtuar leu\u00e7emin\u00eb.<\/p>\n P\u00ebrmes eksperimenteve t\u00eb m\u00ebtejshme, studiuesit zbuluan se aspergomicinat ka t\u00eb ngjar\u00eb t\u00eb prishin procesin e ndarjes qelizore.<\/p>\n Ve\u00e7an\u00ebrisht, komponimet kishin pak ose aspak efekt n\u00eb qelizat e kancerit t\u00eb gjirit, m\u00ebl\u00e7is\u00eb ose mushk\u00ebrive, duke sugjeruar q\u00eb efektet e aspergomicinave jan\u00eb specifike p\u00ebr lloje t\u00eb caktuara qelizash, nj\u00eb tipar thelb\u00ebsor p\u00ebr \u00e7do trajtim t\u00eb ardhsh\u00ebm me ila\u00e7e.<\/p>\n Studiuesit identifikuan grupe t\u00eb ngjashme gjenesh n\u00eb k\u00ebrpudha t\u00eb tjera, duke sugjeruar se mbeten p\u00ebr t\u2019u zbuluar m\u00eb shum\u00eb RiPPS k\u00ebrpudhore. Hapi tjet\u00ebr \u00ebsht\u00eb testimi i aspergomicinave n\u00eb modelet shtazore, me shpres\u00ebn q\u00eb nj\u00eb dit\u00eb t\u00eb kalohet n\u00eb provat klinike tek njer\u00ebzit.<\/p>\n","protected":false},"excerpt":{"rendered":" 28 Qershor 2025 Studiues t\u00eb udh\u00ebhequr nga Universiteti i Pensilvanis\u00eb e kan\u00eb shnd\u00ebrruar k\u00ebrpudh\u00ebn vdekjeprur\u00ebse Aspergillus flavus, e lidhur me mallkimin e faraon\u00ebve, n\u00eb nj\u00eb p\u00ebrb\u00ebr\u00ebs t\u00eb fuqish\u00ebm q\u00eb lufton kancerin, duke hapur rrug\u00eb t\u00eb reja p\u00ebr zbulimin e m\u00eb shum\u00eb ila\u00e7eve me baz\u00eb k\u00ebrpudhat. Pasi arkeolog\u00ebt hap\u00ebn varrin e mbretit Tutankhamun n\u00eb vitet 1920, […]<\/p>\n","protected":false},"author":9,"featured_media":92835,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[27,85,35],"tags":[],"class_list":["post-92834","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blogu-i-udhetarit","category-histori","category-shoqerore"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/06\/900-0-1750749424xscreenshot-16-878.webp?fit=900%2C513&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5Z6wp-o9k","jetpack-related-posts":[{"id":76094,"url":"https:\/\/www.shqiperia.com\/blog\/besohej-se-sillte-vdekjen-zgjidhet-misteri-i-mallkimit-te-faraoneve\/","url_meta":{"origin":92834,"position":0},"title":"Besohej se sillte vdekjen, zgjidhet misteri i \u201cmallkimit t\u00eb faraon\u00ebve\u201d","author":"Kurt Farka","date":"December 6, 2023","format":false,"excerpt":"6 Dhjetor 2023 Nj\u00eb shekull m\u00eb par\u00eb, m\u00eb 4 n\u00ebntor 1922, lordi britanik Carnarvon dhe nj\u00eb ekip arkeolog\u00ebsh hap\u00ebn p\u00ebr her\u00eb t\u00eb par\u00eb varrin e faraonit Tutankhamen. N\u00eb muajt dhe vitet pas zbulimit, disa prej personave q\u00eb hyn\u00eb n\u00eb dhom\u00ebn e err\u00ebt dhe plot pluhur, vdiq\u00ebn n\u00eb rrethana misterioze q\u00eb\u2026","rel":"","context":"In "Arte"","block_context":{"text":"Arte","link":"https:\/\/www.shqiperia.com\/blog\/category\/arte\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/tutankhamen.jpg?fit=720%2C405&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/tutankhamen.jpg?fit=720%2C405&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/tutankhamen.jpg?fit=720%2C405&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/tutankhamen.jpg?fit=720%2C405&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":38300,"url":"https:\/\/www.shqiperia.com\/blog\/te-verteta-apo-jo-keto-jane-6-prej-mallkimeve-me-te-njohura-ne-histori\/","url_meta":{"origin":92834,"position":1},"title":"T\u00eb v\u00ebrteta apo jo? K\u00ebto jan\u00eb 6 prej mallkimeve m\u00eb t\u00eb njohura n\u00eb histori","author":"Kurt Farka","date":"September 11, 2020","format":false,"excerpt":"T\u00eb v\u00ebrteta apo jo? K\u00ebto jan\u00eb 6 prej mallkimeve m\u00eb t\u00eb njohura n\u00eb histori Nj\u00ebr\u00ebzit mund t\u00eb jen\u00eb shum\u00eb supersticioz\u00eb, por ndonj\u00ebher\u00eb disa mallkime historike duken shum\u00eb t\u00eb v\u00ebrteta, p\u00ebr t\u00eb qen\u00eb rast\u00ebsi apo bestytni t\u00eb thjeshta. K\u00ebto jan\u00eb 6 prej mallkimeve m\u00eb t\u00eb famshme historike: - Mallkimi i Otzi-t\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2020\/09\/785-0-5f4ba8bf0661f.jpg?fit=785%2C485&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2020\/09\/785-0-5f4ba8bf0661f.jpg?fit=785%2C485&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2020\/09\/785-0-5f4ba8bf0661f.jpg?fit=785%2C485&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2020\/09\/785-0-5f4ba8bf0661f.jpg?fit=785%2C485&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":93875,"url":"https:\/\/www.shqiperia.com\/blog\/byzylyku-prej-ari-nga-epoka-e-faraoneve-vidhet-ne-kajro-dhe-perfundon-ne-nje-fonderi\/","url_meta":{"origin":92834,"position":2},"title":"Byzylyku prej ari nga epoka e faraon\u00ebve vidhet ne Kajro dhe p\u00ebrfundon n\u00eb nj\u00eb fonderi.","author":"Kurt Farka","date":"September 21, 2025","format":false,"excerpt":"22 Shtator 2025 Nj\u00eb byzylyk ari \u00ebsht\u00eb zhdukur nga laboratori i restaurimit t\u00eb Muzeut t\u00eb Kajros n\u00eb Sheshin Tahrir, i cili p\u00ebr vite me radh\u00eb ka qen\u00eb n\u00eb qend\u00ebr t\u00eb nj\u00eb transferimi t\u00eb mundimsh\u00ebm t\u00eb artefakteve n\u00eb Muzeun e Ri Egjiptian n\u00eb Giza. BBC e zbuloi k\u00ebt\u00eb, duke cituar Ministrin\u00eb\u2026","rel":"","context":"In "Arte"","block_context":{"text":"Arte","link":"https:\/\/www.shqiperia.com\/blog\/category\/arte\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/09\/auto_bracelet_2-800x4291758279383-1.jpg?fit=900%2C483&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/09\/auto_bracelet_2-800x4291758279383-1.jpg?fit=900%2C483&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/09\/auto_bracelet_2-800x4291758279383-1.jpg?fit=900%2C483&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/09\/auto_bracelet_2-800x4291758279383-1.jpg?fit=900%2C483&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":94756,"url":"https:\/\/www.shqiperia.com\/blog\/arkeologet-gjejne-varrin-5000-vjecar-mund-te-jete-porta-per-mbreterine-prehistorike\/","url_meta":{"origin":92834,"position":3},"title":"Arkeolog\u00ebt gjejn\u00eb varrin 5000-vje\u00e7ar: Mund t\u00eb jet\u00eb ‘porta’ p\u00ebr mbret\u00ebrin\u00eb prehistorike","author":"Kurt Farka","date":"November 9, 2025","format":false,"excerpt":"9 Nentor 2025 Arkeolog\u00ebt n\u00eb Kin\u00eb zbuluan k\u00ebt\u00eb vjesht\u00eb nj\u00eb seri varresh n\u00eb rr\u00ebnojat e Wangzhuang n\u00eb provinc\u00ebn Henan, duke p\u00ebrfshir\u00eb varrin M27, i cili besohet se i p\u00ebrkiste nj\u00eb mbreti parahistorik. Madh\u00ebsia e varrit, arkivolit dhe boll\u00ebku i objekteve t\u00eb gjetura sugjerojn\u00eb se ky vend mund t\u00eb ket\u00eb qen\u00eb\u2026","rel":"","context":"In "Histori"","block_context":{"text":"Histori","link":"https:\/\/www.shqiperia.com\/blog\/category\/histori\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/11\/640-0-34148e98b43ab0699ef159613af7a606.webp?fit=640%2C360&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/11\/640-0-34148e98b43ab0699ef159613af7a606.webp?fit=640%2C360&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/11\/640-0-34148e98b43ab0699ef159613af7a606.webp?fit=640%2C360&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":53061,"url":"https:\/\/www.shqiperia.com\/blog\/e-padegjuar-artisti-i-njohur-nderton-varrin-e-tij-ne-fshatin-personal-prej-4-4-milione-eurosh\/","url_meta":{"origin":92834,"position":4},"title":"E pad\u00ebgjuar! Artisti i njohur nd\u00ebrton varrin e tij n\u00eb fshatin personal prej 4.4 milion\u00eb eurosh","author":"Kurt Farka","date":"January 14, 2022","format":false,"excerpt":"E pad\u00ebgjuar! Artisti i njohur nd\u00ebrton varrin e tij n\u00eb fshatin personal prej 4.4 milion\u00eb eurosh 14 JANAR 2022 Artisti Ed Sheeran i ka \u00e7uditur t\u00eb gjith\u00eb, ka b\u00ebr\u00eb plane p\u00ebr t\u00eb nd\u00ebrtuar nj\u00eb dhom\u00eb varrimi n\u00ebn dyshemen\u00eb e kish\u00ebs s\u00eb re n\u00eb form\u00eb varke e cila po ngrihet n\u00eb\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2022\/01\/Artisti-i-njohur-nderton-varrin-e-tij-prej-4.4-milione-eurosh-2.jpg?fit=561%2C323&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2022\/01\/Artisti-i-njohur-nderton-varrin-e-tij-prej-4.4-milione-eurosh-2.jpg?fit=561%2C323&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2022\/01\/Artisti-i-njohur-nderton-varrin-e-tij-prej-4.4-milione-eurosh-2.jpg?fit=561%2C323&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":50921,"url":"https:\/\/www.shqiperia.com\/blog\/dita-e-te-shumteve-te-te-pareve-tone-ne-nje-zbulimi-arkeologjik-ne-durres-gjate-realizimit-te-tij-derdhej-uje-vere-qumesht-ose-mjalt-mbi-varrin-e-te-vdekurit\/","url_meta":{"origin":92834,"position":5},"title":"Dita e \u201cTe Shumteve\u201d, te Te Pareve Tone ne nje zbulimi arkeologjik ne Durres. – “Gjat\u00eb realizimit t\u00eb tij derdhej uj\u00eb, ver\u00eb, qum\u00ebsht ose mjalt mbi varrin e t\u00eb vdekurit”.","author":"Kurt Farka","date":"October 27, 2021","format":false,"excerpt":"Dita e \u201cTe Shumteve\u201d, te Te Pareve Tone ne nje zbulimi arkeologjik ne Durres. \"Gjat\u00eb realizimit t\u00eb tij derdhej uj\u00eb, ver\u00eb, qum\u00ebsht ose mjalt mbi varrin e t\u00eb vdekurit\". Lexo Lajmin nga: \u00a0Amfora.Al, Durres: \u201cRefrigerium\u201d, zbulohet p\u00ebr her\u00eb t\u00eb par\u00eb riti i ve\u00e7ant\u00eb i varrimit Gjat\u00eb g\u00ebrmimeve t\u00eb realizuara n\u00eb\u2026","rel":"","context":"In "Histori"","block_context":{"text":"Histori","link":"https:\/\/www.shqiperia.com\/blog\/category\/histori\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2021\/10\/Perkujtimi-i-te-vdekurve-Arkeologji.jpg?fit=526%2C274&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2021\/10\/Perkujtimi-i-te-vdekurve-Arkeologji.jpg?fit=526%2C274&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2021\/10\/Perkujtimi-i-te-vdekurve-Arkeologji.jpg?fit=526%2C274&ssl=1&resize=525%2C300 1.5x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts\/92834","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/comments?post=92834"}],"version-history":[{"count":1,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts\/92834\/revisions"}],"predecessor-version":[{"id":92836,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts\/92834\/revisions\/92836"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/media\/92835"}],"wp:attachment":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/media?parent=92834"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/categories?post=92834"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/tags?post=92834"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}