{"id":92834,"date":"2025-06-28T08:47:11","date_gmt":"2025-06-28T08:47:11","guid":{"rendered":"https:\/\/www.shqiperia.com\/blog\/?p=92834"},"modified":"2025-06-28T08:47:11","modified_gmt":"2025-06-28T08:47:11","slug":"kerpudha-toksike-e-lidhur-me-mallkimin-e-faraoneve-shnderrohet-ne-ilac-per-leucemine","status":"publish","type":"post","link":"https:\/\/www.shqiperia.com\/blog\/kerpudha-toksike-e-lidhur-me-mallkimin-e-faraoneve-shnderrohet-ne-ilac-per-leucemine\/","title":{"rendered":"K\u00ebrpudha toksike e lidhur me \u2018mallkimin e Faraon\u00ebve\u2019 shnd\u00ebrrohet n\u00eb ila\u00e7 p\u00ebr leu\u00e7emin\u00eb"},"content":{"rendered":"

\"\"<\/p>\n

28 Qershor 2025<\/p>\n

Studiues t\u00eb udh\u00ebhequr nga Universiteti i Pensilvanis\u00eb e kan\u00eb shnd\u00ebrruar k\u00ebrpudh\u00ebn vdekjeprur\u00ebse Aspergillus flavus, e lidhur me mallkimin e faraon\u00ebve, n\u00eb nj\u00eb p\u00ebrb\u00ebr\u00ebs t\u00eb fuqish\u00ebm q\u00eb lufton kancerin, duke hapur rrug\u00eb t\u00eb reja p\u00ebr zbulimin e m\u00eb shum\u00eb ila\u00e7eve me baz\u00eb k\u00ebrpudhat.<\/p>\n

Pasi arkeolog\u00ebt hap\u00ebn varrin e mbretit Tutankhamun n\u00eb vitet 1920, nj\u00eb seri vdekjesh t\u00eb parakohshme midis ekipit t\u00eb g\u00ebrmimeve nxit\u00ebn thashethemet p\u00ebr nj\u00eb mallkim t\u00eb faraonit. Dekada m\u00eb von\u00eb, mjek\u00ebt teorizuan se sporet e k\u00ebrpudhave, t\u00eb fjetura p\u00ebr mij\u00ebvje\u00e7ar\u00eb, mund t\u00eb ken\u00eb luajtur nj\u00eb rol.<\/p>\n

N\u00eb vitet 1970, dymb\u00ebdhjet\u00eb shkenc\u00ebtar\u00eb hyn\u00eb n\u00eb varrin e Kazimirit IV n\u00eb Poloni. Brenda pak jav\u00ebsh, dhjet\u00eb prej tyre vdiq\u00ebn. Hulumtimet e m\u00ebvonshme zbuluan se varri p\u00ebrmbante Aspergillus flavus, toksinat e t\u00eb cilit mund t\u00eb \u00e7ojn\u00eb n\u00eb infeksione t\u00eb mushk\u00ebrive, ve\u00e7an\u00ebrisht tek njer\u00ebzit me sistem imunitar t\u00eb dob\u00ebsua.<\/p>\n

Tani, e nj\u00ebjta k\u00ebrpudh\u00eb \u00ebsht\u00eb burimi i nj\u00eb trajtimi t\u00eb ri premtues p\u00ebr kancerin.<\/p>\n

\u201cK\u00ebrpudhat na dhan\u00eb penicilin\u00eb. K\u00ebto rezultate tregojn\u00eb se ka shum\u00eb m\u00eb tep\u00ebr ila\u00e7e t\u00eb nxjerra nga produkte natyrore q\u00eb mund t\u00eb gjenden\u201d,<\/em>\u00a0thot\u00eb Sheri Gao, profesoresh\u00eb e asociuar e Inxhinieris\u00eb Kimike dhe Biomolekulare dhe Bioteknologjis\u00eb dhe autore kryesore e punimit n\u00eb Nature Chemical Biology.<\/p>\n

Trajtimi n\u00eb fjal\u00eb \u00ebsht\u00eb nj\u00eb klas\u00eb peptidesh t\u00eb sintetizuara n\u00eb ribosom dhe t\u00eb modifikuara pas p\u00ebrkthimit (RiPP). Nd\u00ebrsa mij\u00ebra RiPP jan\u00eb identifikuar n\u00eb baktere, vet\u00ebm disa jan\u00eb gjetur n\u00eb k\u00ebrpudha. P\u00ebr t\u00eb gjetur m\u00eb shum\u00eb RiPP nga k\u00ebrpudhat, studiuesit studiuan s\u00eb pari nj\u00eb duzin\u00eb llojesh t\u00eb Aspergillus, t\u00eb cilat hulumtimet e m\u00ebparshme kishin sugjeruar se mund t\u00eb p\u00ebrmbanin m\u00eb shum\u00eb nga k\u00ebto kimikate, dhe zbuluan se Aspergillus flavus mbante premtimin m\u00eb t\u00eb madh p\u00ebr studime t\u00eb m\u00ebtejshme.<\/p>\n

Pas pastrimit t\u00eb kat\u00ebr RiPP-ve t\u00eb ndryshme, studiuesit zbuluan se molekulat ndanin nj\u00eb struktur\u00eb unike t\u00eb unazave t\u00eb nd\u00ebrlidhura. Studiuesit i em\u00ebruan k\u00ebto molekula, t\u00eb cilat nuk ishin p\u00ebrshkruar kurr\u00eb m\u00eb par\u00eb, sipas k\u00ebrpudh\u00ebs n\u00eb t\u00eb cil\u00ebn u gjet\u00ebn: aspergillomicina.<\/p>\n

Edhe pa modifikim, kur u p\u00ebrzien me qelizat kancerogjene njer\u00ebzore, aspergomicinat treguan premtim mjek\u00ebsor: dy nga kat\u00ebr variantet kishin efekte t\u00eb fuqishme kund\u00ebr qelizave t\u00eb leu\u00e7emis\u00eb. Nj\u00eb variant tjet\u00ebr, t\u00eb cilit studiuesit i shtuan nj\u00eb lipid, ose molekul\u00eb yndyrore, q\u00eb gjendet gjithashtu n\u00eb pelten\u00eb mbret\u00ebrore q\u00eb ushqen blet\u00ebt n\u00eb zhvillim, funksionoi po aq mir\u00eb sa citarabina dhe daunorubicina, dy ila\u00e7e t\u00eb miratuara nga FDA q\u00eb jan\u00eb p\u00ebrdorur p\u00ebr dekada p\u00ebr t\u00eb trajtuar leu\u00e7emin\u00eb.<\/p>\n

P\u00ebrmes eksperimenteve t\u00eb m\u00ebtejshme, studiuesit zbuluan se aspergomicinat ka t\u00eb ngjar\u00eb t\u00eb prishin procesin e ndarjes qelizore.<\/p>\n

Ve\u00e7an\u00ebrisht, komponimet kishin pak ose aspak efekt n\u00eb qelizat e kancerit t\u00eb gjirit, m\u00ebl\u00e7is\u00eb ose mushk\u00ebrive, duke sugjeruar q\u00eb efektet e aspergomicinave jan\u00eb specifike p\u00ebr lloje t\u00eb caktuara qelizash, nj\u00eb tipar thelb\u00ebsor p\u00ebr \u00e7do trajtim t\u00eb ardhsh\u00ebm me ila\u00e7e.<\/p>\n

Studiuesit identifikuan grupe t\u00eb ngjashme gjenesh n\u00eb k\u00ebrpudha t\u00eb tjera, duke sugjeruar se mbeten p\u00ebr t\u2019u zbuluar m\u00eb shum\u00eb RiPPS k\u00ebrpudhore. Hapi tjet\u00ebr \u00ebsht\u00eb testimi i aspergomicinave n\u00eb modelet shtazore, me shpres\u00ebn q\u00eb nj\u00eb dit\u00eb t\u00eb kalohet n\u00eb provat klinike tek njer\u00ebzit.<\/p>\n","protected":false},"excerpt":{"rendered":"

28 Qershor 2025 Studiues t\u00eb udh\u00ebhequr nga Universiteti i Pensilvanis\u00eb e kan\u00eb shnd\u00ebrruar k\u00ebrpudh\u00ebn vdekjeprur\u00ebse Aspergillus flavus, e lidhur me mallkimin e faraon\u00ebve, n\u00eb nj\u00eb p\u00ebrb\u00ebr\u00ebs t\u00eb fuqish\u00ebm q\u00eb lufton kancerin, duke hapur rrug\u00eb t\u00eb reja p\u00ebr zbulimin e m\u00eb shum\u00eb ila\u00e7eve me baz\u00eb k\u00ebrpudhat. Pasi arkeolog\u00ebt hap\u00ebn varrin e mbretit Tutankhamun n\u00eb vitet 1920, […]<\/p>\n","protected":false},"author":9,"featured_media":92835,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[27,85,35],"tags":[],"class_list":["post-92834","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blogu-i-udhetarit","category-histori","category-shoqerore"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/06\/900-0-1750749424xscreenshot-16-878.webp?fit=900%2C513&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5Z6wp-o9k","jetpack-related-posts":[{"id":100741,"url":"https:\/\/www.shqiperia.com\/blog\/nje-kryeveper-etruske-qeveria-italiane-blen-15-milione-euro-varrin-e-francois\/","url_meta":{"origin":92834,"position":0},"title":"Nj\u00eb kryevep\u00ebr etruske, qeveria italiane blen 15 milion\u00eb euro varrin e Francois","author":"Kurt Farka","date":"May 30, 2026","format":false,"excerpt":"30 Maji 2026 Varri i famsh\u00ebm i Fran\u00e7ois Vulci b\u00ebhet zyrtarisht pjes\u00eb e trash\u00ebgimis\u00eb shtet\u00ebrore italiane. Nj\u00eb nga kryeveprat m\u00eb t\u00eb r\u00ebnd\u00ebsishme t\u00eb piktur\u00ebs etruske dhe antike \u00ebsht\u00eb bler\u00eb nga Shteti Italian dhe me n\u00ebnshkrimin e aktit t\u00eb shitjes, i cili u zhvillua sot n\u00eb Ministrin\u00eb e Kultur\u00ebs, vepra i\u2026","rel":"","context":"In "Histori"","block_context":{"text":"Histori","link":"https:\/\/www.shqiperia.com\/blog\/category\/histori\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/auto_VARRI1780066838.jpg?fit=900%2C495&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/auto_VARRI1780066838.jpg?fit=900%2C495&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/auto_VARRI1780066838.jpg?fit=900%2C495&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/auto_VARRI1780066838.jpg?fit=900%2C495&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":76094,"url":"https:\/\/www.shqiperia.com\/blog\/besohej-se-sillte-vdekjen-zgjidhet-misteri-i-mallkimit-te-faraoneve\/","url_meta":{"origin":92834,"position":1},"title":"Besohej se sillte vdekjen, zgjidhet misteri i \u201cmallkimit t\u00eb faraon\u00ebve\u201d","author":"Kurt Farka","date":"December 6, 2023","format":false,"excerpt":"6 Dhjetor 2023 Nj\u00eb shekull m\u00eb par\u00eb, m\u00eb 4 n\u00ebntor 1922, lordi britanik Carnarvon dhe nj\u00eb ekip arkeolog\u00ebsh hap\u00ebn p\u00ebr her\u00eb t\u00eb par\u00eb varrin e faraonit Tutankhamen. N\u00eb muajt dhe vitet pas zbulimit, disa prej personave q\u00eb hyn\u00eb n\u00eb dhom\u00ebn e err\u00ebt dhe plot pluhur, vdiq\u00ebn n\u00eb rrethana misterioze q\u00eb\u2026","rel":"","context":"In "Arte"","block_context":{"text":"Arte","link":"https:\/\/www.shqiperia.com\/blog\/category\/arte\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/tutankhamen.jpg?fit=720%2C405&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/tutankhamen.jpg?fit=720%2C405&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/tutankhamen.jpg?fit=720%2C405&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/tutankhamen.jpg?fit=720%2C405&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":100295,"url":"https:\/\/www.shqiperia.com\/blog\/puthja-e-ndrenikes-per-veliajn-piktori-haliti-lufta-behet-per-varrin-babai-im-eshte-varrosur-ngjitur-me-moikom-zeqon-dhe-ska-vend-per-lulet\/","url_meta":{"origin":92834,"position":2},"title":"Puthja e Ndrenik\u00ebs p\u00ebr Veliajn, piktori Haliti: – Lufta b\u00ebhet p\u00ebr varrin, babai im \u00ebsht\u00eb varrosur ngjitur me Moikom Zeqon dhe s\u2019ka vend p\u00ebr lulet","author":"Kurt Farka","date":"May 15, 2026","format":false,"excerpt":"15 Maji 2026 N\u00eb podcastin e fundit \u201cFlet\u201d me Ilnisa Agollin, i ftuar ishte piktori i njohur, Helidon Haliti. P\u00ebrve\u00e7 rr\u00ebfimit mbi jet\u00ebn e tij dhe marr\u00ebdh\u00ebnien me koleg\u00ebt, ai foli edhe p\u00ebr nj\u00eb ngjarje aktuale, q\u00eb ka ngjallur mjaft reagim. Ai u pyet n\u00eb lidhje me takimin e ngroht\u00eb,\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/Helidon-Haliti.webp?fit=800%2C450&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/Helidon-Haliti.webp?fit=800%2C450&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/Helidon-Haliti.webp?fit=800%2C450&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/Helidon-Haliti.webp?fit=800%2C450&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":104594,"url":"https:\/\/www.shqiperia.com\/blog\/qeveria-hungareze-ve-zyrtarisht-nen-hetim-pronarin-e-one-albania\/","url_meta":{"origin":92834,"position":3},"title":"Qeveria hungareze v\u00eb zyrtarisht n\u00ebn hetim pronarin e One Albania","author":"Kurt Farka","date":"August 17, 2026","format":false,"excerpt":"17 Gusht 2026 Qeveria hungareze ka urdh\u00ebruar nj\u00eb hetim gjith\u00ebp\u00ebrfshir\u00ebs mbi marr\u00ebdh\u00ebnien midis Grupit 4iG dhe shtetit hungarez, dhe Kryeministri P\u00e9ter Magyar u ka k\u00ebrkuar kat\u00ebr prej ministrave t\u00eb tij t\u00eb raportojn\u00eb mbi rezultatet e hetimit. Ministri i Ekonomis\u00eb dhe Energjis\u00eb Istv\u00e1n Kapit\u00e1ny, Ministri i Mbrojtjes Romulusz Ruszin-Szendi, Ministri i\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/08\/auto_-1000-0-1778574113xgello-6231786884514.jpg?fit=893%2C575&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/08\/auto_-1000-0-1778574113xgello-6231786884514.jpg?fit=893%2C575&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/08\/auto_-1000-0-1778574113xgello-6231786884514.jpg?fit=893%2C575&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/08\/auto_-1000-0-1778574113xgello-6231786884514.jpg?fit=893%2C575&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":104824,"url":"https:\/\/www.shqiperia.com\/blog\/5-figura-te-njohura-historike-qe-nuk-kane-ekzistuar\/","url_meta":{"origin":92834,"position":4},"title":"5 figura t\u00eb njohura historike q\u00eb nuk kan\u00eb ekzistuar","author":"Kurt Farka","date":"August 20, 2026","format":false,"excerpt":"20 Gusht 2026 Historia \u00ebsht\u00eb plot me figura t\u00eb famshme, fjal\u00ebt dhe veprat e t\u00eb cilave kan\u00eb jehuar nd\u00ebr shekuj. 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