{"id":90311,"date":"2025-03-12T00:39:53","date_gmt":"2025-03-12T00:39:53","guid":{"rendered":"https:\/\/www.shqiperia.com\/blog\/?p=90311"},"modified":"2025-03-12T00:39:53","modified_gmt":"2025-03-12T00:39:53","slug":"pse-truri-i-grave-plaket-me-pak-se-ai-i-burrave","status":"publish","type":"post","link":"https:\/\/www.shqiperia.com\/blog\/pse-truri-i-grave-plaket-me-pak-se-ai-i-burrave\/","title":{"rendered":"Pse truri i grave plaket m\u00eb pak se ai i burrave?"},"content":{"rendered":"

\"\"<\/p>\n

12 Mars 2025<\/p>\n

Burrat kan\u00eb nj\u00eb kromozom X dhe nj\u00eb Y, nd\u00ebrsa grat\u00eb kan\u00eb dy kromozome X. Shkenc\u00ebtar\u00ebt kan\u00eb besuar p\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb se nj\u00ebri prej kromozomeve X tek grat\u00eb \u00ebsht\u00eb kryesisht joaktiv dhe nuk b\u00ebn shum\u00eb.<\/p>\n

Nj\u00eb studim i ri tregon se ky kromozom i fjetur n\u00eb fakt zgjohet m\u00eb von\u00eb n\u00eb jet\u00eb dhe aktivizon gjene q\u00eb ndihmojn\u00eb trurin t\u00eb mbetet i sh\u00ebndetsh\u00ebm, gj\u00eb q\u00eb mund t\u00eb shpjegoj\u00eb pse grat\u00eb ruajn\u00eb aft\u00ebsit\u00eb e tyre njoh\u00ebse m\u00eb gjat\u00eb se burrat.<\/p>\n

Studiuesit nga Universiteti i Kalifornis\u00eb, San Francisko (UCSF) zbuluan se kur minjt\u00eb femra t\u00eb modifikuar gjenetikisht arrijn\u00eb nj\u00eb mosh\u00eb t\u00eb barasvlershme me rreth 65 vjet tek njer\u00ebzit, kromozomi i tyre “i heshtur” X fillon t\u00eb shpreh\u00eb gjene q\u00eb p\u00ebrmir\u00ebsojn\u00eb lidhjet e trurit dhe rrisin aft\u00ebsit\u00eb njoh\u00ebse.<\/p>\n

\n
<\/ins><\/div>\n<\/div>\n

“N\u00eb plakjen tipike, grat\u00eb kan\u00eb nj\u00eb tru q\u00eb duket m\u00eb i ri, me m\u00eb pak deficite njoh\u00ebse krahasuar me burrat,” tha dr. Dena Dubal, profesoresh\u00eb e neurologjis\u00eb n\u00eb UCSF. “K\u00ebto rezultate tregojn\u00eb se kromozomi X i heshtur tek grat\u00eb n\u00eb fakt rizgjohet n\u00eb fund t\u00eb jet\u00ebs, ndoshta duke ndihmuar n\u00eb ngadal\u00ebsimin e r\u00ebnies njoh\u00ebse.”<\/p>\n

Ekipi i Dubal-it mati shprehjen e gjeneve n\u00eb hipokamp, struktur\u00ebn e trurit q\u00eb \u00ebsht\u00eb p\u00ebrgjegj\u00ebse p\u00ebr t\u00eb nx\u00ebnit dhe kujtes\u00ebn.<\/p>\n

Studiuesit u habit\u00ebn kur zbuluan se kromozomi X, q\u00eb mendohej se ishte joaktiv, shprehte rreth 20 gjene n\u00eb disa lloje qelizash t\u00eb hipokampit. Shum\u00eb prej k\u00ebtyre gjeneve lidhen me zhvillimin e trurit dhe aft\u00ebsin\u00eb intelektuale.<\/p>\n

“Plakja kishte zgjuar kromozomin X t\u00eb fjetur,” tha Dubal.<\/p>\n

“Menj\u00ebher\u00eb menduam se kjo mund t\u00eb shpjegoj\u00eb pse truri i grave mbetet m\u00eb i q\u00ebndruesh\u00ebm gjat\u00eb plakjes, sepse burrat nuk e kan\u00eb k\u00ebt\u00eb X shtes\u00eb,” shtoi Margaret Gadek, studente e diplomuar n\u00eb UCSF dhe autore kryesore e studimit.<\/p>\n

Studiuesit e UCSF dyshojn\u00eb se \u00e7el\u00ebsi mund t\u00eb jet\u00eb PLP1, nj\u00eb gjen q\u00eb kodon protein\u00ebn kryesore t\u00eb mielin\u00ebs, e cila izolon fibrat nervore n\u00eb tru dhe palc\u00ebn kurrizore.<\/p>\n

Minjt\u00eb femra t\u00eb moshuara kishin m\u00eb shum\u00eb PLP1 n\u00eb hipokamp sesa minjt\u00eb meshkuj t\u00eb moshuar. Kur ekipi e b\u00ebri q\u00eb PLP1 t\u00eb shprehej artificialisht n\u00eb hipokampin e t\u00eb dy gjinive, minjt\u00eb u paraqit\u00ebn m\u00eb mir\u00eb n\u00eb testet e t\u00eb nx\u00ebnit dhe kujtes\u00ebs.<\/p>\n

Nj\u00eb analiz\u00eb e indeve t\u00eb trurit t\u00eb dhuruara nga burra dhe gra t\u00eb moshuara konfirmoi se vet\u00ebm grat\u00eb kishin nivele t\u00eb larta t\u00eb PLP1.<\/p>\n

Gjetjet e UCSF-s\u00eb u publikuan k\u00ebt\u00eb jav\u00eb n\u00eb revist\u00ebn Science Advances.<\/p>\n

Dubal dhe koleg\u00ebt e saj po eksplorojn\u00eb n\u00ebse kromozomi i dyt\u00eb X \u00ebsht\u00eb aktiv tek grat\u00eb e moshuara dhe si mund t\u00eb ndihmoj\u00eb n\u00eb rigjall\u00ebrimin e trurit t\u00eb plakur.<\/p>\n

“Aft\u00ebsit\u00eb njoh\u00ebse jan\u00eb nj\u00eb nga sfidat m\u00eb t\u00eb m\u00ebdha biomjek\u00ebsore, por truri i plakur ka ende potencial p\u00ebr ndryshim, dhe kromozomi X qart\u00ebsisht mund t\u00eb na m\u00ebsoj\u00eb se \u00e7far\u00eb \u00ebsht\u00eb e mundur,” tha Dubal. “A mund t\u00eb ket\u00eb nd\u00ebrhyrje q\u00eb rrisin shprehjen e gjeneve si PLP1 nga kromozomi X p\u00ebr t\u00eb ngadal\u00ebsuar r\u00ebnien, si tek grat\u00eb ashtu edhe tek burrat, nd\u00ebrsa plakemi?”\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

12 Mars 2025 Burrat kan\u00eb nj\u00eb kromozom X dhe nj\u00eb Y, nd\u00ebrsa grat\u00eb kan\u00eb dy kromozome X. Shkenc\u00ebtar\u00ebt kan\u00eb besuar p\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb se nj\u00ebri prej kromozomeve X tek grat\u00eb \u00ebsht\u00eb kryesisht joaktiv dhe nuk b\u00ebn shum\u00eb. Nj\u00eb studim i ri tregon se ky kromozom i fjetur n\u00eb fakt zgjohet m\u00eb von\u00eb n\u00eb […]<\/p>\n","protected":false},"author":9,"featured_media":90312,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[27,1,35],"tags":[],"class_list":["post-90311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blogu-i-udhetarit","category-njoftime-shtypi","category-shoqerore"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/03\/auto_Screenshot_151741637507-1.jpg?fit=900%2C584&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5Z6wp-nuD","jetpack-related-posts":[{"id":103364,"url":"https:\/\/www.shqiperia.com\/blog\/odisea-i-matt-damon-dhe-odisea-i-bekim-fehmiut\/","url_meta":{"origin":90311,"position":0},"title":"ODISEA I MATT DAMON DHE ODISEA I BEKIM FEHMIUT","author":"Kurt Farka","date":"July 28, 2026","format":false,"excerpt":"28 Korrik 2026 Nga Ben Blushi Dy dit\u00ebt e fundit pash\u00eb dy Odise. 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