{"id":90311,"date":"2025-03-12T00:39:53","date_gmt":"2025-03-12T00:39:53","guid":{"rendered":"https:\/\/www.shqiperia.com\/blog\/?p=90311"},"modified":"2025-03-12T00:39:53","modified_gmt":"2025-03-12T00:39:53","slug":"pse-truri-i-grave-plaket-me-pak-se-ai-i-burrave","status":"publish","type":"post","link":"https:\/\/www.shqiperia.com\/blog\/pse-truri-i-grave-plaket-me-pak-se-ai-i-burrave\/","title":{"rendered":"Pse truri i grave plaket m\u00eb pak se ai i burrave?"},"content":{"rendered":"

\"\"<\/p>\n

12 Mars 2025<\/p>\n

Burrat kan\u00eb nj\u00eb kromozom X dhe nj\u00eb Y, nd\u00ebrsa grat\u00eb kan\u00eb dy kromozome X. Shkenc\u00ebtar\u00ebt kan\u00eb besuar p\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb se nj\u00ebri prej kromozomeve X tek grat\u00eb \u00ebsht\u00eb kryesisht joaktiv dhe nuk b\u00ebn shum\u00eb.<\/p>\n

Nj\u00eb studim i ri tregon se ky kromozom i fjetur n\u00eb fakt zgjohet m\u00eb von\u00eb n\u00eb jet\u00eb dhe aktivizon gjene q\u00eb ndihmojn\u00eb trurin t\u00eb mbetet i sh\u00ebndetsh\u00ebm, gj\u00eb q\u00eb mund t\u00eb shpjegoj\u00eb pse grat\u00eb ruajn\u00eb aft\u00ebsit\u00eb e tyre njoh\u00ebse m\u00eb gjat\u00eb se burrat.<\/p>\n

Studiuesit nga Universiteti i Kalifornis\u00eb, San Francisko (UCSF) zbuluan se kur minjt\u00eb femra t\u00eb modifikuar gjenetikisht arrijn\u00eb nj\u00eb mosh\u00eb t\u00eb barasvlershme me rreth 65 vjet tek njer\u00ebzit, kromozomi i tyre “i heshtur” X fillon t\u00eb shpreh\u00eb gjene q\u00eb p\u00ebrmir\u00ebsojn\u00eb lidhjet e trurit dhe rrisin aft\u00ebsit\u00eb njoh\u00ebse.<\/p>\n

\n
<\/ins><\/div>\n<\/div>\n

“N\u00eb plakjen tipike, grat\u00eb kan\u00eb nj\u00eb tru q\u00eb duket m\u00eb i ri, me m\u00eb pak deficite njoh\u00ebse krahasuar me burrat,” tha dr. Dena Dubal, profesoresh\u00eb e neurologjis\u00eb n\u00eb UCSF. “K\u00ebto rezultate tregojn\u00eb se kromozomi X i heshtur tek grat\u00eb n\u00eb fakt rizgjohet n\u00eb fund t\u00eb jet\u00ebs, ndoshta duke ndihmuar n\u00eb ngadal\u00ebsimin e r\u00ebnies njoh\u00ebse.”<\/p>\n

Ekipi i Dubal-it mati shprehjen e gjeneve n\u00eb hipokamp, struktur\u00ebn e trurit q\u00eb \u00ebsht\u00eb p\u00ebrgjegj\u00ebse p\u00ebr t\u00eb nx\u00ebnit dhe kujtes\u00ebn.<\/p>\n

Studiuesit u habit\u00ebn kur zbuluan se kromozomi X, q\u00eb mendohej se ishte joaktiv, shprehte rreth 20 gjene n\u00eb disa lloje qelizash t\u00eb hipokampit. Shum\u00eb prej k\u00ebtyre gjeneve lidhen me zhvillimin e trurit dhe aft\u00ebsin\u00eb intelektuale.<\/p>\n

“Plakja kishte zgjuar kromozomin X t\u00eb fjetur,” tha Dubal.<\/p>\n

“Menj\u00ebher\u00eb menduam se kjo mund t\u00eb shpjegoj\u00eb pse truri i grave mbetet m\u00eb i q\u00ebndruesh\u00ebm gjat\u00eb plakjes, sepse burrat nuk e kan\u00eb k\u00ebt\u00eb X shtes\u00eb,” shtoi Margaret Gadek, studente e diplomuar n\u00eb UCSF dhe autore kryesore e studimit.<\/p>\n

Studiuesit e UCSF dyshojn\u00eb se \u00e7el\u00ebsi mund t\u00eb jet\u00eb PLP1, nj\u00eb gjen q\u00eb kodon protein\u00ebn kryesore t\u00eb mielin\u00ebs, e cila izolon fibrat nervore n\u00eb tru dhe palc\u00ebn kurrizore.<\/p>\n

Minjt\u00eb femra t\u00eb moshuara kishin m\u00eb shum\u00eb PLP1 n\u00eb hipokamp sesa minjt\u00eb meshkuj t\u00eb moshuar. Kur ekipi e b\u00ebri q\u00eb PLP1 t\u00eb shprehej artificialisht n\u00eb hipokampin e t\u00eb dy gjinive, minjt\u00eb u paraqit\u00ebn m\u00eb mir\u00eb n\u00eb testet e t\u00eb nx\u00ebnit dhe kujtes\u00ebs.<\/p>\n

Nj\u00eb analiz\u00eb e indeve t\u00eb trurit t\u00eb dhuruara nga burra dhe gra t\u00eb moshuara konfirmoi se vet\u00ebm grat\u00eb kishin nivele t\u00eb larta t\u00eb PLP1.<\/p>\n

Gjetjet e UCSF-s\u00eb u publikuan k\u00ebt\u00eb jav\u00eb n\u00eb revist\u00ebn Science Advances.<\/p>\n

Dubal dhe koleg\u00ebt e saj po eksplorojn\u00eb n\u00ebse kromozomi i dyt\u00eb X \u00ebsht\u00eb aktiv tek grat\u00eb e moshuara dhe si mund t\u00eb ndihmoj\u00eb n\u00eb rigjall\u00ebrimin e trurit t\u00eb plakur.<\/p>\n

“Aft\u00ebsit\u00eb njoh\u00ebse jan\u00eb nj\u00eb nga sfidat m\u00eb t\u00eb m\u00ebdha biomjek\u00ebsore, por truri i plakur ka ende potencial p\u00ebr ndryshim, dhe kromozomi X qart\u00ebsisht mund t\u00eb na m\u00ebsoj\u00eb se \u00e7far\u00eb \u00ebsht\u00eb e mundur,” tha Dubal. “A mund t\u00eb ket\u00eb nd\u00ebrhyrje q\u00eb rrisin shprehjen e gjeneve si PLP1 nga kromozomi X p\u00ebr t\u00eb ngadal\u00ebsuar r\u00ebnien, si tek grat\u00eb ashtu edhe tek burrat, nd\u00ebrsa plakemi?”\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

12 Mars 2025 Burrat kan\u00eb nj\u00eb kromozom X dhe nj\u00eb Y, nd\u00ebrsa grat\u00eb kan\u00eb dy kromozome X. Shkenc\u00ebtar\u00ebt kan\u00eb besuar p\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb se nj\u00ebri prej kromozomeve X tek grat\u00eb \u00ebsht\u00eb kryesisht joaktiv dhe nuk b\u00ebn shum\u00eb. Nj\u00eb studim i ri tregon se ky kromozom i fjetur n\u00eb fakt zgjohet m\u00eb von\u00eb n\u00eb […]<\/p>\n","protected":false},"author":9,"featured_media":90312,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[27,1,35],"tags":[],"class_list":["post-90311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blogu-i-udhetarit","category-njoftime-shtypi","category-shoqerore"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/03\/auto_Screenshot_151741637507-1.jpg?fit=900%2C584&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5Z6wp-nuD","jetpack-related-posts":[{"id":75852,"url":"https:\/\/www.shqiperia.com\/blog\/kjo-eshte-arsyeja-pse-burrat-vdesin-me-heret-se-grate\/","url_meta":{"origin":90311,"position":0},"title":"Kjo \u00ebsht\u00eb arsyeja pse burrat vdesin m\u00eb her\u00ebt se grat\u00eb","author":"Kurt Farka","date":"November 27, 2023","format":false,"excerpt":"27 Nentor 2023 Askush nuk do t\u00eb jetoj\u00eb p\u00ebrgjithmon\u00eb. Q\u00ebndrimi yn\u00eb n\u00eb tok\u00eb do t\u00eb p\u00ebrfundoj\u00eb n\u00eb nj\u00eb moment, ne thjesht nuk e dim\u00eb se kur. Ajo q\u00eb dim\u00eb \u00ebsht\u00eb se, mesatarisht, grat\u00eb jetojn\u00eb m\u00eb gjat\u00eb se burrat. \u00c7far\u00eb e arsyeton k\u00ebt\u00eb ndryshim?\u00a0M\u00eb posht\u00eb do t\u00eb shohim arsyet. Hormonet Nj\u00eb\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/11\/9D3991B5-3F5F-4A27-82A8-9950DD7037DC.jpeg?fit=665%2C400&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/11\/9D3991B5-3F5F-4A27-82A8-9950DD7037DC.jpeg?fit=665%2C400&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/11\/9D3991B5-3F5F-4A27-82A8-9950DD7037DC.jpeg?fit=665%2C400&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":77897,"url":"https:\/\/www.shqiperia.com\/blog\/arrestohen-20-gazetare-ne-moske-mes-tyre-dhe-te-huaj\/","url_meta":{"origin":90311,"position":1},"title":"Arrestohen 20 gazetar\u00eb n\u00eb Mosk\u00eb, mes tyre dhe t\u00eb huaj","author":"Kurt Farka","date":"February 3, 2024","format":false,"excerpt":"3 Shkurt 2024 T\u00eb pakt\u00ebn nj\u00ebzet gazetar\u00eb, p\u00ebrfshir\u00eb disa t\u00eb huaj, u arrestuan n\u00eb Mosk\u00eb gjat\u00eb nj\u00eb mitingu t\u00eb organizuar n\u00eb Sheshin e Kuq nga grat\u00eb e ushtar\u00ebve q\u00eb luftonin n\u00eb Ukrain\u00eb dhe k\u00ebrkonin kthimin e burrave t\u00eb tyre nga fronti. Nj\u00eb video-gazetar i AFP-s\u00eb i arrestuar gjat\u00eb k\u00ebsaj demonstrate\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2024\/02\/0p0p-0o-.jpg?fit=785%2C445&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2024\/02\/0p0p-0o-.jpg?fit=785%2C445&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2024\/02\/0p0p-0o-.jpg?fit=785%2C445&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2024\/02\/0p0p-0o-.jpg?fit=785%2C445&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":76637,"url":"https:\/\/www.shqiperia.com\/blog\/grate-prehistorike-ishin-me-te-afta-ne-gjueti-se-burrat-thote-studimi\/","url_meta":{"origin":90311,"position":2},"title":"Grat\u00eb prehistorike ishin m\u00eb t\u00eb afta n\u00eb gjueti se burrat, thot\u00eb studimi.","author":"Kurt Farka","date":"December 25, 2023","format":false,"excerpt":"25 Dhjetor 2023 Profesor Ocobock tha: \"Meqen\u00ebse yndyra p\u00ebrmban m\u00eb shum\u00eb kalori sesa karbohidratet, \u00ebsht\u00eb nj\u00eb djegie m\u00eb e gjat\u00eb dhe m\u00eb e ngadalt\u00eb, q\u00eb do t\u00eb thot\u00eb se e nj\u00ebjta energji e q\u00ebndrueshme mund t\u00eb t\u00eb mbaj\u00eb m\u00eb gjat\u00eb dhe mund t\u00eb vonoj\u00eb lodhjen. \"Estrogjeni \u00ebsht\u00eb me t\u00eb v\u00ebrtet\u00eb\u2026","rel":"","context":"In "Histori"","block_context":{"text":"Histori","link":"https:\/\/www.shqiperia.com\/blog\/category\/histori\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/auto_Screenshot_21701434430-1.jpg?fit=900%2C521&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/auto_Screenshot_21701434430-1.jpg?fit=900%2C521&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/auto_Screenshot_21701434430-1.jpg?fit=900%2C521&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2023\/12\/auto_Screenshot_21701434430-1.jpg?fit=900%2C521&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":25150,"url":"https:\/\/www.shqiperia.com\/blog\/studimi-ja-vendet-ku-grate-dhe-burrat-jetojne-me-gjate\/","url_meta":{"origin":90311,"position":3},"title":"Studimi: – Ja vendet ku grat\u00eb dhe burrat jetojn\u00eb m\u00eb gjat\u00eb. –","author":"Kurt Farka","date":"August 26, 2019","format":false,"excerpt":"Studimi: - Ja vendet ku grat\u00eb dhe burrat jetojn\u00eb m\u00eb gjat\u00eb. - Nj\u00eb studim i ri ka nxjerr\u00eb p\u00ebrfundime v\u00ebrtet interesante, sa i p\u00ebrket jet\u00ebgjat\u00ebsis\u00eb s\u00eb burrave dhe grave n\u00eb mbar\u00eb bot\u00ebn. Ekspert\u00ebt kan\u00eb studiuar jet\u00ebgjat\u00ebsin\u00eb n\u00eb 15 vende t\u00eb m\u00ebdha dhe kan\u00eb arritur n\u00eb p\u00ebrfundimin, se femrat jetojn\u00eb n\u00eb\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2019\/08\/auto_24jeta1566649267-770x394.png?fit=770%2C394&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2019\/08\/auto_24jeta1566649267-770x394.png?fit=770%2C394&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2019\/08\/auto_24jeta1566649267-770x394.png?fit=770%2C394&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2019\/08\/auto_24jeta1566649267-770x394.png?fit=770%2C394&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":50039,"url":"https:\/\/www.shqiperia.com\/blog\/plot-me-femra-njihuni-me-qytetin-ku-grate-bejne-ligjin\/","url_meta":{"origin":90311,"position":4},"title":"Plot me femra, njihuni me qytetin ku grat\u00eb \u201cb\u00ebjn\u00eb ligjin\u201d","author":"Kurt Farka","date":"September 22, 2021","format":false,"excerpt":"Plot me femra, njihuni me qytetin ku grat\u00eb \u201cb\u00ebjn\u00eb ligjin\u201d 22 SHTATOR 2021 Do t'ju b\u00ebj\u00eb habi po t\u00eb d\u00ebgjoni p\u00ebr Noiva do Cordeiro, nj\u00eb qytet brazilian ku jetojn\u00eb vet\u00ebm gra. Ishte Maria Senorina de Lima q\u00eb e \"themeloi\" n\u00eb vitin 1981, e cila u d\u00ebbua m\u00eb pas nga fshati\u2026","rel":"","context":"In "Press Releases"","block_context":{"text":"Press Releases","link":"https:\/\/www.shqiperia.com\/blog\/category\/press-releases\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2021\/09\/640-0-dc77fcfe31a5c878488788750b6cbd32.jpg?fit=640%2C360&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2021\/09\/640-0-dc77fcfe31a5c878488788750b6cbd32.jpg?fit=640%2C360&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2021\/09\/640-0-dc77fcfe31a5c878488788750b6cbd32.jpg?fit=640%2C360&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":51109,"url":"https:\/\/www.shqiperia.com\/blog\/grate-kane-me-shume-tru-nga-burrat\/","url_meta":{"origin":90311,"position":5},"title":"Grat\u00eb kan\u00eb m\u00eb shum\u00eb tru nga burrat?","author":"Kurt Farka","date":"November 6, 2021","format":false,"excerpt":"Grat\u00eb kan\u00eb m\u00eb shum\u00eb tru nga burrat? 27 tetor 2021 Dr. Adem Harxhi N\u00eb 1986 k\u00ebrkuesit zbuluan nj\u00eb ndryshim midis trurit t\u00eb femrave dhe trurit t\u00eb meshkujve. Tufa nervore q\u00eb lidh hemisfer\u00ebn e djatht\u00eb me t\u00eb majt\u00ebn (Corpus callosum), \u00ebsht\u00eb m\u00eb i trash\u00eb dhe m\u00eb i pasur me lidhje nervore\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2021\/11\/unnamed.jpg?fit=449%2C223&ssl=1&resize=350%2C200","width":350,"height":200},"classes":[]}],"_links":{"self":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts\/90311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/comments?post=90311"}],"version-history":[{"count":1,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts\/90311\/revisions"}],"predecessor-version":[{"id":90313,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts\/90311\/revisions\/90313"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/media\/90312"}],"wp:attachment":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/media?parent=90311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/categories?post=90311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/tags?post=90311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}