{"id":90311,"date":"2025-03-12T00:39:53","date_gmt":"2025-03-12T00:39:53","guid":{"rendered":"https:\/\/www.shqiperia.com\/blog\/?p=90311"},"modified":"2025-03-12T00:39:53","modified_gmt":"2025-03-12T00:39:53","slug":"pse-truri-i-grave-plaket-me-pak-se-ai-i-burrave","status":"publish","type":"post","link":"https:\/\/www.shqiperia.com\/blog\/pse-truri-i-grave-plaket-me-pak-se-ai-i-burrave\/","title":{"rendered":"Pse truri i grave plaket m\u00eb pak se ai i burrave?"},"content":{"rendered":"

\"\"<\/p>\n

12 Mars 2025<\/p>\n

Burrat kan\u00eb nj\u00eb kromozom X dhe nj\u00eb Y, nd\u00ebrsa grat\u00eb kan\u00eb dy kromozome X. Shkenc\u00ebtar\u00ebt kan\u00eb besuar p\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb se nj\u00ebri prej kromozomeve X tek grat\u00eb \u00ebsht\u00eb kryesisht joaktiv dhe nuk b\u00ebn shum\u00eb.<\/p>\n

Nj\u00eb studim i ri tregon se ky kromozom i fjetur n\u00eb fakt zgjohet m\u00eb von\u00eb n\u00eb jet\u00eb dhe aktivizon gjene q\u00eb ndihmojn\u00eb trurin t\u00eb mbetet i sh\u00ebndetsh\u00ebm, gj\u00eb q\u00eb mund t\u00eb shpjegoj\u00eb pse grat\u00eb ruajn\u00eb aft\u00ebsit\u00eb e tyre njoh\u00ebse m\u00eb gjat\u00eb se burrat.<\/p>\n

Studiuesit nga Universiteti i Kalifornis\u00eb, San Francisko (UCSF) zbuluan se kur minjt\u00eb femra t\u00eb modifikuar gjenetikisht arrijn\u00eb nj\u00eb mosh\u00eb t\u00eb barasvlershme me rreth 65 vjet tek njer\u00ebzit, kromozomi i tyre “i heshtur” X fillon t\u00eb shpreh\u00eb gjene q\u00eb p\u00ebrmir\u00ebsojn\u00eb lidhjet e trurit dhe rrisin aft\u00ebsit\u00eb njoh\u00ebse.<\/p>\n

\n
<\/ins><\/div>\n<\/div>\n

“N\u00eb plakjen tipike, grat\u00eb kan\u00eb nj\u00eb tru q\u00eb duket m\u00eb i ri, me m\u00eb pak deficite njoh\u00ebse krahasuar me burrat,” tha dr. Dena Dubal, profesoresh\u00eb e neurologjis\u00eb n\u00eb UCSF. “K\u00ebto rezultate tregojn\u00eb se kromozomi X i heshtur tek grat\u00eb n\u00eb fakt rizgjohet n\u00eb fund t\u00eb jet\u00ebs, ndoshta duke ndihmuar n\u00eb ngadal\u00ebsimin e r\u00ebnies njoh\u00ebse.”<\/p>\n

Ekipi i Dubal-it mati shprehjen e gjeneve n\u00eb hipokamp, struktur\u00ebn e trurit q\u00eb \u00ebsht\u00eb p\u00ebrgjegj\u00ebse p\u00ebr t\u00eb nx\u00ebnit dhe kujtes\u00ebn.<\/p>\n

Studiuesit u habit\u00ebn kur zbuluan se kromozomi X, q\u00eb mendohej se ishte joaktiv, shprehte rreth 20 gjene n\u00eb disa lloje qelizash t\u00eb hipokampit. Shum\u00eb prej k\u00ebtyre gjeneve lidhen me zhvillimin e trurit dhe aft\u00ebsin\u00eb intelektuale.<\/p>\n

“Plakja kishte zgjuar kromozomin X t\u00eb fjetur,” tha Dubal.<\/p>\n

“Menj\u00ebher\u00eb menduam se kjo mund t\u00eb shpjegoj\u00eb pse truri i grave mbetet m\u00eb i q\u00ebndruesh\u00ebm gjat\u00eb plakjes, sepse burrat nuk e kan\u00eb k\u00ebt\u00eb X shtes\u00eb,” shtoi Margaret Gadek, studente e diplomuar n\u00eb UCSF dhe autore kryesore e studimit.<\/p>\n

Studiuesit e UCSF dyshojn\u00eb se \u00e7el\u00ebsi mund t\u00eb jet\u00eb PLP1, nj\u00eb gjen q\u00eb kodon protein\u00ebn kryesore t\u00eb mielin\u00ebs, e cila izolon fibrat nervore n\u00eb tru dhe palc\u00ebn kurrizore.<\/p>\n

Minjt\u00eb femra t\u00eb moshuara kishin m\u00eb shum\u00eb PLP1 n\u00eb hipokamp sesa minjt\u00eb meshkuj t\u00eb moshuar. Kur ekipi e b\u00ebri q\u00eb PLP1 t\u00eb shprehej artificialisht n\u00eb hipokampin e t\u00eb dy gjinive, minjt\u00eb u paraqit\u00ebn m\u00eb mir\u00eb n\u00eb testet e t\u00eb nx\u00ebnit dhe kujtes\u00ebs.<\/p>\n

Nj\u00eb analiz\u00eb e indeve t\u00eb trurit t\u00eb dhuruara nga burra dhe gra t\u00eb moshuara konfirmoi se vet\u00ebm grat\u00eb kishin nivele t\u00eb larta t\u00eb PLP1.<\/p>\n

Gjetjet e UCSF-s\u00eb u publikuan k\u00ebt\u00eb jav\u00eb n\u00eb revist\u00ebn Science Advances.<\/p>\n

Dubal dhe koleg\u00ebt e saj po eksplorojn\u00eb n\u00ebse kromozomi i dyt\u00eb X \u00ebsht\u00eb aktiv tek grat\u00eb e moshuara dhe si mund t\u00eb ndihmoj\u00eb n\u00eb rigjall\u00ebrimin e trurit t\u00eb plakur.<\/p>\n

“Aft\u00ebsit\u00eb njoh\u00ebse jan\u00eb nj\u00eb nga sfidat m\u00eb t\u00eb m\u00ebdha biomjek\u00ebsore, por truri i plakur ka ende potencial p\u00ebr ndryshim, dhe kromozomi X qart\u00ebsisht mund t\u00eb na m\u00ebsoj\u00eb se \u00e7far\u00eb \u00ebsht\u00eb e mundur,” tha Dubal. “A mund t\u00eb ket\u00eb nd\u00ebrhyrje q\u00eb rrisin shprehjen e gjeneve si PLP1 nga kromozomi X p\u00ebr t\u00eb ngadal\u00ebsuar r\u00ebnien, si tek grat\u00eb ashtu edhe tek burrat, nd\u00ebrsa plakemi?”\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

12 Mars 2025 Burrat kan\u00eb nj\u00eb kromozom X dhe nj\u00eb Y, nd\u00ebrsa grat\u00eb kan\u00eb dy kromozome X. Shkenc\u00ebtar\u00ebt kan\u00eb besuar p\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb se nj\u00ebri prej kromozomeve X tek grat\u00eb \u00ebsht\u00eb kryesisht joaktiv dhe nuk b\u00ebn shum\u00eb. Nj\u00eb studim i ri tregon se ky kromozom i fjetur n\u00eb fakt zgjohet m\u00eb von\u00eb n\u00eb […]<\/p>\n","protected":false},"author":9,"featured_media":90312,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[27,1,35],"tags":[],"class_list":["post-90311","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blogu-i-udhetarit","category-njoftime-shtypi","category-shoqerore"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/03\/auto_Screenshot_151741637507-1.jpg?fit=900%2C584&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5Z6wp-nuD","jetpack-related-posts":[{"id":100388,"url":"https:\/\/www.shqiperia.com\/blog\/pse-kurani-ishte-nder-librat-me-te-shitur-mes-te-krishtereve-ne-ameriken-e-shekullit-xviii\/","url_meta":{"origin":90311,"position":0},"title":"Pse Kurani ishte nd\u00ebr librat m\u00eb t\u00eb shitur mes t\u00eb krishter\u00ebve n\u00eb Amerik\u00ebn e shekullit XVIII","author":"Kurt Farka","date":"May 18, 2026","format":false,"excerpt":"18 Maji 2026 Islami ka ekzistuar n\u00eb Amerik\u00ebn e Veriut prej qindra vitesh, q\u00eb kur njer\u00ebzit e skllav\u00ebruar t\u00eb sjell\u00eb me forc\u00eb nga Afrika soll\u00ebn me vete edhe fen\u00eb e tyre. N\u00eb vitet 1700, nj\u00eb p\u00ebrkthim anglisht i Kuranit u b\u00eb madje nd\u00ebr librat m\u00eb t\u00eb shitur mes protestant\u00ebve n\u00eb\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/640-0-kurani-1778963834-1.jpeg?fit=640%2C320&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/640-0-kurani-1778963834-1.jpeg?fit=640%2C320&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/640-0-kurani-1778963834-1.jpeg?fit=640%2C320&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":102173,"url":"https:\/\/www.shqiperia.com\/blog\/shteti-i-kapur-prova-eshte-aruba-lubonja-ne-vend-te-arrestojne-ramen-per-korrupsionin-ndalojne-protestuesit-pse-hodhen-veze-balla-provokoi\/","url_meta":{"origin":90311,"position":1},"title":"\u201cShteti i kapur, prova \u00ebsht\u00eb Aruba\u201d- Lubonja: N\u00eb vend t\u00eb arrestojn\u00eb Ram\u00ebn p\u00ebr korrupsionin, ndalojn\u00eb protestuesit pse hodh\u00ebn vez\u00eb! Balla provokoi","author":"Kurt Farka","date":"July 2, 2026","format":false,"excerpt":"2 Korrik 2026 Analisti Fatos Lubonja komentoi protest\u00ebn e qytetar\u00ebve dhe aktivist\u00ebve sot para parlamentit, ku Policia ushtroi dhun\u00eb me gaz lotsjell\u00ebs, spraj me piper dhe topa uji, duke shoq\u00ebruar edhe t\u00eb pakt\u00ebn 20 prej tyre me forc\u00eb. 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Disa analist\u00eb presin q\u00eb \u00e7mimet t\u00eb vazhdojn\u00eb t\u00eb rriten mes nj\u00eb mjedisi\u2026","rel":"","context":"In "Njoftime Shtypi"","block_context":{"text":"Njoftime Shtypi","link":"https:\/\/www.shqiperia.com\/blog\/category\/njoftime-shtypi\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/900-0-1757092900xshutterstock-2480509399-2024-08-368b960cfc07a7fc6986b47f60f0159d-scaled-298.webp?fit=900%2C506&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/900-0-1757092900xshutterstock-2480509399-2024-08-368b960cfc07a7fc6986b47f60f0159d-scaled-298.webp?fit=900%2C506&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/900-0-1757092900xshutterstock-2480509399-2024-08-368b960cfc07a7fc6986b47f60f0159d-scaled-298.webp?fit=900%2C506&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/900-0-1757092900xshutterstock-2480509399-2024-08-368b960cfc07a7fc6986b47f60f0159d-scaled-298.webp?fit=900%2C506&ssl=1&resize=700%2C400 2x"},"classes":[]},{"id":101089,"url":"https:\/\/www.shqiperia.com\/blog\/bulevardi-deshmoret-e-kombit-mbushet-plot-protestuesit-i-pergjigjen-policise-femijet-dhe-grate-udheheqin-marshimin\/","url_meta":{"origin":90311,"position":3},"title":"Bulevardi \u201cD\u00ebshmor\u00ebt e Kombit\u201d mbushet plot, protestuesit i p\u00ebrgjigjen policis\u00eb, f\u00ebmij\u00ebt dhe grat\u00eb udh\u00ebheqin marshimin","author":"Kurt Farka","date":"June 4, 2026","format":false,"excerpt":"4 Qershor 2026 Bulevardi \u201cD\u00ebshmor\u00ebt e Kombit\u201d \u00ebsht\u00eb mbushur me protestues q\u00eb i jan\u00eb bashkuar tubimit kund\u00ebr projektit p\u00ebr nd\u00ebrtimin e resortit turistik n\u00eb zon\u00ebn e mbrojtur t\u00eb Zv\u00ebrnecit. 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Jan\u00eb me dhjet\u00ebra sheshe italiane ku emigrant\u00ebt shqiptar\u00eb po shprehin solidaritetin dhe zem\u00ebrimin e tyre ndaj qeveris\u00eb s\u00eb Tiran\u00ebs, duke iu bashkuar protestave q\u00eb prej dit\u00ebsh kan\u00eb p\u00ebrfshir\u00eb Shqip\u00ebrin\u00eb. 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Kalor\u00ebsit Templar\u00eb nuk k\u00ebrkuan tok\u00eb, pasuri apo tituj. Premtuan vet\u00ebm nj\u00eb gj\u00eb: t\u00eb mbronin pelegrin\u00ebt q\u00eb udh\u00ebtonin drejt Tok\u00ebs s\u00eb Shenjt\u00eb. Por brenda pak dekadash, ky grup i vog\u00ebl luft\u00ebtar\u00ebsh u shnd\u00ebrrua n\u00eb\u2026","rel":"","context":"In "Histori"","block_context":{"text":"Histori","link":"https:\/\/www.shqiperia.com\/blog\/category\/histori\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/auto_Kaloresit-Templare_11778842861.jpg?fit=826%2C588&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/auto_Kaloresit-Templare_11778842861.jpg?fit=826%2C588&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/auto_Kaloresit-Templare_11778842861.jpg?fit=826%2C588&ssl=1&resize=525%2C300 1.5x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/05\/auto_Kaloresit-Templare_11778842861.jpg?fit=826%2C588&ssl=1&resize=700%2C400 2x"},"classes":[]}],"_links":{"self":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts\/90311","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/comments?post=90311"}],"version-history":[{"count":1,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts\/90311\/revisions"}],"predecessor-version":[{"id":90313,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/posts\/90311\/revisions\/90313"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/media\/90312"}],"wp:attachment":[{"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/media?parent=90311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/categories?post=90311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.shqiperia.com\/blog\/wp-json\/wp\/v2\/tags?post=90311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}