![\"\"](\"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/01\/640-0-alzh-1736523606.jpeg?resize=582%2C388&ssl=1\")
<\/p>\n<\/p>\n
11 Janar 2025<\/p>\n
Studiuesit izraelit\u00eb kan\u00eb zbuluar nj\u00eb lidhje befasuese midis s\u00ebmundjes s\u00eb Alzheimerit dhe virusit herpes simplex-1 (HSV-1), duke ofruar njohuri t\u00eb reja se si virusi mund t\u00eb ndikoj\u00eb n\u00eb p\u00ebrparimin e \u00e7rregullimit neurodegjenerativ.<\/p>\n
Udh\u00ebhequr nga Ose Shemesh i Fakultetit t\u00eb Farmacis\u00eb t\u00eb Universitetit Hebraik t\u00eb Jerusalemit, studiuesit kan\u00eb identifikuar 19 proteina t\u00eb lidhura me HSV-1 n\u00eb trurin e individ\u00ebve me Alzheimer.<\/p>\n
Duke p\u00ebrdorur teknika t\u00eb avancuara, ata gjet\u00ebn k\u00ebto proteina n\u00eb t\u00eb gjitha fazat e s\u00ebmundjes, duke forcuar provat n\u00eb rritje se infeksionet si HSV-1 mund t\u00eb luajn\u00eb nj\u00eb rol n\u00eb zhvillimin e saj.<\/p>\n
Studimi zbuloi se ICP27, nj\u00eb protein\u00eb HSV-1, b\u00ebhet m\u00eb aktive nd\u00ebrsa s\u00ebmundja e Alzheimerit p\u00ebrparon. Kjo protein\u00eb z\u00eb t\u00eb nj\u00ebjtat rajone si proteinat tau, t\u00eb cilat jan\u00eb qendrore p\u00ebr Alzheimer, por nuk shfaqen pran\u00eb pllakave amiloide.<\/p>\n
Pllakat amiloide jan\u00eb grumbuj fragmentesh proteinash q\u00eb nd\u00ebrtohen midis neuroneve n\u00eb tru. Specifikimi sugjeron q\u00eb HSV-1 mund t\u00eb luaj\u00eb nj\u00eb rol t\u00eb drejtp\u00ebrdrejt\u00eb n\u00eb ndikimin e patologjis\u00eb tau.<\/p>\n
ICP27 \u00ebsht\u00eb v\u00ebrejtur n\u00eb t\u00eb nj\u00ebjtat rajone si proteinat tau, t\u00eb cilat b\u00ebhen toksike n\u00eb Alzheimer.<\/p>\n
\u00cbsht\u00eb interesante se kjo protein\u00eb nuk u gjet pran\u00eb pllakave amiloide, nj\u00eb tjet\u00ebr shenj\u00eb dalluese e s\u00ebmundjes, duke sugjeruar se ndikimi i HSV-1 mund t\u00eb p\u00ebrfshij\u00eb kryesisht procese t\u00eb lidhura me tau.<\/p>\n
Eksperimentet e m\u00ebtejshme duke p\u00ebrdorur organoidet e trurit, modele miniatur\u00eb t\u00eb trurit q\u00eb rrjedhin nga qelizat burimore, treguan se infeksioni HSV-1 mund t\u00eb ndryshoj\u00eb proteinat tau n\u00eb vende specifike t\u00eb lidhura me Alzheimer.<\/p>\n
N\u00eb fillim t\u00eb s\u00ebmundjes, k\u00ebto ndryshime dukej se mbronin qelizat e trurit duke kufizuar virusin dhe duke parandaluar vdekjen e qelizave. Megjithat\u00eb, nd\u00ebrsa s\u00ebmundja p\u00ebrparonte, t\u00eb nj\u00ebjtat ndryshime kontribuan n\u00eb neurodegjenerimin.<\/p>\n
Studimi gjithashtu theksoi reagimin imunitar natyral t\u00eb trurit, ve\u00e7an\u00ebrisht rrug\u00ebn cGAS-STING e cila \u00ebsht\u00eb pjes\u00eb e sistemit mbrojt\u00ebs t\u00eb trurit. cGAS-STING ndikon n\u00eb ndryshimet e tau dhe mund t\u00eb kontribuoj\u00eb pa dashje n\u00eb d\u00ebmtimin e par\u00eb n\u00eb Alzheimer.<\/p>\n
Gjetjet sugjerojn\u00eb se synimi i aktivitetit t\u00eb HSV-1 ose modifikimi i p\u00ebrgjigjes imune t\u00eb trurit mund t\u00eb hap\u00eb rrug\u00ebn p\u00ebr trajtime inovative.<\/p>\n
P\u00ebrve\u00e7 k\u00ebsaj, njer\u00ebzit me nj\u00eb histori t\u00eb HSV-1 mund t\u00eb p\u00ebrfitojn\u00eb nga trajtimet e rregullta antivirale p\u00ebr t\u00eb parandaluar komplikimet e mundshme t\u00eb lidhura me Alzheimer.<\/p>\n","protected":false},"excerpt":{"rendered":"
11 Janar 2025 Studiuesit izraelit\u00eb kan\u00eb zbuluar nj\u00eb lidhje befasuese midis s\u00ebmundjes s\u00eb Alzheimerit dhe virusit herpes simplex-1 (HSV-1), duke ofruar njohuri t\u00eb reja se si virusi mund t\u00eb ndikoj\u00eb n\u00eb p\u00ebrparimin e \u00e7rregullimit neurodegjenerativ. Udh\u00ebhequr nga Ose Shemesh i Fakultetit t\u00eb Farmacis\u00eb t\u00eb Universitetit Hebraik t\u00eb Jerusalemit, studiuesit kan\u00eb identifikuar 19 proteina t\u00eb lidhura […]<\/p>\n","protected":false},"author":9,"featured_media":88259,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[27,1,35],"tags":[],"class_list":["post-88258","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blogu-i-udhetarit","category-njoftime-shtypi","category-shoqerore"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/01\/640-0-alzh-1736523606.jpeg?fit=640%2C427&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5Z6wp-mXw","jetpack-related-posts":[{"id":18377,"url":"https:\/\/www.shqiperia.com\/blog\/zbulohet-proteina-qe-shkakton-alzheimerin-humbjen-e-kujteses\/","url_meta":{"origin":88258,"position":0},"title":"Zbulohet proteina q\u00eb shkakton Alzheimerin, (Humbjen e Kujteses).-","author":"Kurt Farka","date":"March 15, 2019","format":false,"excerpt":"Zbulohet proteina q\u00eb shkakton Alzheimerin, (Humbjen e Kujteses).- \u00a0 \u201cNj\u00eb test gjaku q\u00eb v\u00eb n\u00eb dukje shenjat e d\u00ebmtimit t\u00eb trurit mund t\u00eb p\u00ebrdoret p\u00ebr t\u00eb zbuluar s\u00ebmundjen e Alzheimerit deri n\u00eb nj\u00eb dekad\u00eb p\u00ebrpara se t\u00eb shfaqen simptomat\u201d, than\u00eb shkenc\u00ebtar\u00ebt. N\u00eb nj\u00eb studim t\u00eb b\u00ebr\u00eb tek 247 njer\u00ebz, me\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2019\/03\/BBSz51f-640x480.jpg?fit=640%2C480&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2019\/03\/BBSz51f-640x480.jpg?fit=640%2C480&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2019\/03\/BBSz51f-640x480.jpg?fit=640%2C480&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":100039,"url":"https:\/\/www.shqiperia.com\/blog\/zbulohet-origjina-e-hantavirusit-qe-pushtoi-kroceren-dhe-ka-alarmuar-boten-burimi-i-perhapjes-ishte-ne\/","url_meta":{"origin":88258,"position":1},"title":"Zbulohet origjina e Hantavirusit q\u00eb \u2018pushtoi\u2019 kro\u00e7er\u00ebn dhe ka alarmuar bot\u00ebn, burimi i p\u00ebrhapjes ishte n\u00eb\u2026","author":"Kurt Farka","date":"May 8, 2026","format":false,"excerpt":"8 Maji 2026 Argjentina \u00ebsht\u00eb n\u00eb qend\u00ebr t\u00eb nj\u00eb hetimi nd\u00ebrkomb\u00ebtar sh\u00ebndet\u00ebsor, pas nj\u00eb shp\u00ebrthimi t\u00eb Hantavirusit n\u00eb anijen turistike holandeze MV Hondius, me autoritetet q\u00eb po hetojn\u00eb nj\u00eb deponi (habitat, zon\u00eb t\u00eb kontaminuar) n\u00eb periferi t\u00eb Ushuaia-s, n\u00eb pjes\u00ebn jugore t\u00eb vendit, si nj\u00eb burim t\u00eb mundsh\u00ebm infeksioni. 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