![\"\"](\"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/01\/640-0-alzh-1736523606.jpeg?resize=582%2C388&ssl=1\")
<\/p>\n<\/p>\n
11 Janar 2025<\/p>\n
Studiuesit izraelit\u00eb kan\u00eb zbuluar nj\u00eb lidhje befasuese midis s\u00ebmundjes s\u00eb Alzheimerit dhe virusit herpes simplex-1 (HSV-1), duke ofruar njohuri t\u00eb reja se si virusi mund t\u00eb ndikoj\u00eb n\u00eb p\u00ebrparimin e \u00e7rregullimit neurodegjenerativ.<\/p>\n
Udh\u00ebhequr nga Ose Shemesh i Fakultetit t\u00eb Farmacis\u00eb t\u00eb Universitetit Hebraik t\u00eb Jerusalemit, studiuesit kan\u00eb identifikuar 19 proteina t\u00eb lidhura me HSV-1 n\u00eb trurin e individ\u00ebve me Alzheimer.<\/p>\n
Duke p\u00ebrdorur teknika t\u00eb avancuara, ata gjet\u00ebn k\u00ebto proteina n\u00eb t\u00eb gjitha fazat e s\u00ebmundjes, duke forcuar provat n\u00eb rritje se infeksionet si HSV-1 mund t\u00eb luajn\u00eb nj\u00eb rol n\u00eb zhvillimin e saj.<\/p>\n
Studimi zbuloi se ICP27, nj\u00eb protein\u00eb HSV-1, b\u00ebhet m\u00eb aktive nd\u00ebrsa s\u00ebmundja e Alzheimerit p\u00ebrparon. Kjo protein\u00eb z\u00eb t\u00eb nj\u00ebjtat rajone si proteinat tau, t\u00eb cilat jan\u00eb qendrore p\u00ebr Alzheimer, por nuk shfaqen pran\u00eb pllakave amiloide.<\/p>\n
Pllakat amiloide jan\u00eb grumbuj fragmentesh proteinash q\u00eb nd\u00ebrtohen midis neuroneve n\u00eb tru. Specifikimi sugjeron q\u00eb HSV-1 mund t\u00eb luaj\u00eb nj\u00eb rol t\u00eb drejtp\u00ebrdrejt\u00eb n\u00eb ndikimin e patologjis\u00eb tau.<\/p>\n
ICP27 \u00ebsht\u00eb v\u00ebrejtur n\u00eb t\u00eb nj\u00ebjtat rajone si proteinat tau, t\u00eb cilat b\u00ebhen toksike n\u00eb Alzheimer.<\/p>\n
\u00cbsht\u00eb interesante se kjo protein\u00eb nuk u gjet pran\u00eb pllakave amiloide, nj\u00eb tjet\u00ebr shenj\u00eb dalluese e s\u00ebmundjes, duke sugjeruar se ndikimi i HSV-1 mund t\u00eb p\u00ebrfshij\u00eb kryesisht procese t\u00eb lidhura me tau.<\/p>\n
Eksperimentet e m\u00ebtejshme duke p\u00ebrdorur organoidet e trurit, modele miniatur\u00eb t\u00eb trurit q\u00eb rrjedhin nga qelizat burimore, treguan se infeksioni HSV-1 mund t\u00eb ndryshoj\u00eb proteinat tau n\u00eb vende specifike t\u00eb lidhura me Alzheimer.<\/p>\n
N\u00eb fillim t\u00eb s\u00ebmundjes, k\u00ebto ndryshime dukej se mbronin qelizat e trurit duke kufizuar virusin dhe duke parandaluar vdekjen e qelizave. Megjithat\u00eb, nd\u00ebrsa s\u00ebmundja p\u00ebrparonte, t\u00eb nj\u00ebjtat ndryshime kontribuan n\u00eb neurodegjenerimin.<\/p>\n
Studimi gjithashtu theksoi reagimin imunitar natyral t\u00eb trurit, ve\u00e7an\u00ebrisht rrug\u00ebn cGAS-STING e cila \u00ebsht\u00eb pjes\u00eb e sistemit mbrojt\u00ebs t\u00eb trurit. cGAS-STING ndikon n\u00eb ndryshimet e tau dhe mund t\u00eb kontribuoj\u00eb pa dashje n\u00eb d\u00ebmtimin e par\u00eb n\u00eb Alzheimer.<\/p>\n
Gjetjet sugjerojn\u00eb se synimi i aktivitetit t\u00eb HSV-1 ose modifikimi i p\u00ebrgjigjes imune t\u00eb trurit mund t\u00eb hap\u00eb rrug\u00ebn p\u00ebr trajtime inovative.<\/p>\n
P\u00ebrve\u00e7 k\u00ebsaj, njer\u00ebzit me nj\u00eb histori t\u00eb HSV-1 mund t\u00eb p\u00ebrfitojn\u00eb nga trajtimet e rregullta antivirale p\u00ebr t\u00eb parandaluar komplikimet e mundshme t\u00eb lidhura me Alzheimer.<\/p>\n","protected":false},"excerpt":{"rendered":"
11 Janar 2025 Studiuesit izraelit\u00eb kan\u00eb zbuluar nj\u00eb lidhje befasuese midis s\u00ebmundjes s\u00eb Alzheimerit dhe virusit herpes simplex-1 (HSV-1), duke ofruar njohuri t\u00eb reja se si virusi mund t\u00eb ndikoj\u00eb n\u00eb p\u00ebrparimin e \u00e7rregullimit neurodegjenerativ. Udh\u00ebhequr nga Ose Shemesh i Fakultetit t\u00eb Farmacis\u00eb t\u00eb Universitetit Hebraik t\u00eb Jerusalemit, studiuesit kan\u00eb identifikuar 19 proteina t\u00eb lidhura […]<\/p>\n","protected":false},"author":9,"featured_media":88259,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","default_image_id":0,"font":"","enabled":false},"version":2}},"categories":[27,1,35],"tags":[],"class_list":["post-88258","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blogu-i-udhetarit","category-njoftime-shtypi","category-shoqerore"],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2025\/01\/640-0-alzh-1736523606.jpeg?fit=640%2C427&ssl=1","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p5Z6wp-mXw","jetpack-related-posts":[{"id":18377,"url":"https:\/\/www.shqiperia.com\/blog\/zbulohet-proteina-qe-shkakton-alzheimerin-humbjen-e-kujteses\/","url_meta":{"origin":88258,"position":0},"title":"Zbulohet proteina q\u00eb shkakton Alzheimerin, (Humbjen e Kujteses).-","author":"Kurt Farka","date":"March 15, 2019","format":false,"excerpt":"Zbulohet proteina q\u00eb shkakton Alzheimerin, (Humbjen e Kujteses).- \u00a0 \u201cNj\u00eb test gjaku q\u00eb v\u00eb n\u00eb dukje shenjat e d\u00ebmtimit t\u00eb trurit mund t\u00eb p\u00ebrdoret p\u00ebr t\u00eb zbuluar s\u00ebmundjen e Alzheimerit deri n\u00eb nj\u00eb dekad\u00eb p\u00ebrpara se t\u00eb shfaqen simptomat\u201d, than\u00eb shkenc\u00ebtar\u00ebt. N\u00eb nj\u00eb studim t\u00eb b\u00ebr\u00eb tek 247 njer\u00ebz, me\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2019\/03\/BBSz51f-640x480.jpg?fit=640%2C480&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2019\/03\/BBSz51f-640x480.jpg?fit=640%2C480&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2019\/03\/BBSz51f-640x480.jpg?fit=640%2C480&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":98542,"url":"https:\/\/www.shqiperia.com\/blog\/te-lexuarit-dhe-aktivitetet-mendore-vonojne-fillimin-e-alzheimerit-deri-ne-pese-vjet\/","url_meta":{"origin":88258,"position":1},"title":"T\u00eb lexuarit dhe aktivitetet mendore vonojn\u00eb fillimin e Alzheimerit deri n\u00eb pes\u00eb vjet","author":"Kurt Farka","date":"March 21, 2026","format":false,"excerpt":"21 Mars 2026 Nj\u00eb studim i botuar m\u00eb 11 shkurt 2026 n\u00eb revist\u00ebn \u201cNeurology\u201d tregoi se njer\u00ebzit q\u00eb angazhohen n\u00eb vazhdim\u00ebsi n\u00eb aktivitete mendore stimuluese \u2014 si leximi, shkrimi dhe m\u00ebsimi i gjuh\u00ebve t\u00eb huaja \u2014 mund t\u00eb vonojn\u00eb fillimin e s\u00ebmundjes s\u00eb Alzheimerit deri n\u00eb pes\u00eb vjet dhe t\u00eb\u2026","rel":"","context":"In "Blogu i Udh\u00ebtarit"","block_context":{"text":"Blogu i Udh\u00ebtarit","link":"https:\/\/www.shqiperia.com\/blog\/category\/blogu-i-udhetarit\/"},"img":{"alt_text":"","src":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/03\/640-0-alz-1774002691.jpeg?fit=640%2C448&ssl=1&resize=350%2C200","width":350,"height":200,"srcset":"https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/03\/640-0-alz-1774002691.jpeg?fit=640%2C448&ssl=1&resize=350%2C200 1x, https:\/\/i0.wp.com\/www.shqiperia.com\/blog\/wp-content\/uploads\/2026\/03\/640-0-alz-1774002691.jpeg?fit=640%2C448&ssl=1&resize=525%2C300 1.5x"},"classes":[]},{"id":97966,"url":"https:\/\/www.shqiperia.com\/blog\/ajri-i-ndotur-rrit-rrezikun-per-alzheimer\/","url_meta":{"origin":88258,"position":2},"title":"Ajri i ndotur rrit rrezikun p\u00ebr Alzheimer","author":"Kurt Farka","date":"February 25, 2026","format":false,"excerpt":"25 Shkurt 2026 \u00cbsht\u00eb gjetur nj\u00eb lidhje direkte mes ndotjes s\u00eb ajrit dhe s\u00ebmundjes Alzheimer. \u00cbsht\u00eb v\u00ebrtetuar p\u00ebr her\u00eb t\u00eb par\u00eb shkenc\u00ebrisht se thithja p\u00ebr nj\u00eb koh\u00eb t\u00eb gjat\u00eb e ajrit t\u00eb ndotur rrit rrezikun e zhvillimit t\u00eb s\u00ebmundjes s\u00eb Alzheimerit. 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